Fig. 1 · Structure
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7-Chloro-4-(piperazin-1-yl)quinoline
Chemical Scaffold
7-Chloro-4-(piperazin-1-yl)quinoline is a versatile chemical scaffold utilized in medicinal chemistry, primarily as a potent inhibitor of sirtuins. Additionally, it demonstrates significant inhibition of serotonin uptake with an IC50 of 50 μM. This compound exhibits notable antimalarial activity against D10 and K1 strains of Plasmodium falciparum, with IC50 values of 1.18 μM and 0.97 μM, respectively, making it a valuable tool for malaria research and drug development.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 837-52-5 |
| Applications | Chemical Scaffold |
| Formula | C13H14ClN3 |
| Molecular Weight | 247.72 |
| SMILES | ClC1=CC2=C(C(N3CCNCC3)=CC=N2)C=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.