Fig. 1 · Structure
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(7R)-SBP-0636457
Isomer
(7R)-SBP-0636457 is an isomer of the SMAC mimetic SBP-0636457 and serves as an important experimental control. This compound functions as an inhibitor of inhibitor of apoptosis proteins (IAPs) by binding to their BIR domains, exhibiting a binding affinity (Ki) of 0.27 μM. It is primarily utilized in research focused on solid tumors and hematologic malignancies, contributing to the understanding of cancer therapies that exploit apoptosis pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1422180-61-7 |
| Applications | Isomer |
| Formula | C25H36N4O4 |
| Molecular Weight | 456.58 |
| Synonyms | (7R)-SBI-0636457; (7R)-SB1-0636457 |
| SMILES | O=C([C@H]1C(C)(C)C[C@](N21)([H])OCC[C@H](NC([C@@H](NC)C)=O)C2=O)N[C@@H]3CCCC4=C3C=CC=C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.