Fig. 1 · Structure
Documents & Downloads
SBP-0636457
SMAC Mimetic
SBP-0636457 is a potent SMAC mimetic that functions as an inhibitor of inhibitor of apoptosis (IAP) proteins. By selectively binding to the BIR domains of IAPs, it exhibits a binding affinity with a Ki of 0.27 μM. This compound is primarily utilized in research related to solid tumors and hematologic malignancies, highlighting its potential in cancer therapeutics.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1422180-49-1 |
| Applications | SMAC Mimetic |
| Formula | C25H36N4O4 |
| Molecular Weight | 456.58 |
| Synonyms | SBI-0636457; SB1-0636457 |
| SMILES | O=C([C@@H]1C(C)(C)C[C@](N21)([H])OCC[C@H](NC([C@@H](NC)C)=O)C2=O)N[C@@H]3CCCC4=C3C=CC=C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.