Fig. 1 · Structure
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7ß,27-Dihydroxycholesterol
Cat. No.
A77566
CAS
240129-43-5
RORγt Activator
7ß,27-Dihydroxycholesterol (7β, 27-OHC) is a selective activator of RORγt, exhibiting a Ki of 120 nM. This compound plays a crucial role in promoting the differentiation of CD4+ Th17 cells in both mouse and human models. Additionally, 7ß,27-Dihydroxycholesterol enhances IL-17 production through a CYP27A1-dependent pathway, making it valuable for studies focused on immune response and related signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Activator |
| CAS Number | 240129-43-5 |
| Applications | RORγt Activator |
| Formula | C27H46O3 |
| Molecular Weight | 418.65 |
| Synonyms | 7β; 27-OHC |
| SMILES | C[C@@H](CO)CCC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])[C@@H](O)C=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.