ROR

Cat. No.

A13193

CAS No.

1335106-03-0

SR1001

SR1001 is a selective ROR-alpha and ROR-gamma inverse agonist; suppresses TH17 cell differentiation and inhibits autoimmunity.

Cat. No.

A13568

CAS No.

1359164-11-6

SR-2211

SR-2211 selectively binds RORr(Ki = 105 nM), acting as an inverse agonist of constitutive in vitro RORr activity (IC50 = 320 nM).

Cat. No.

A15245

CAS No.

1246525-60-9

SR1078

SR1078 is an agonist of retinoic acid receptor-related orphan receptors (ROR) RORα/γ; increases transcription of RORα target genes; thought to increase p53 stability.

Cat. No.

A15246

CAS No.

293753-05-6

SR3335

Synonyms: ML-176

SR3335 is a selective RORα synthetic ligand, directly binds to RORα, but not other RORs, and functions as a selective partial inverse agonist of RORα in cell-based assays.

Cat. No.

A16291

CAS No.

1474110-21-8

ROR gamma modulator 1

RORγ modulator 1 is a retinoid-related orphan receptor gamma (RORy) modulator, extracted from patent WO/2015061515 A1, example 124.

Cat. No.

A16863

CAS No.

2055536-64-4

Cintirorgon (LYC-55716)

Synonyms: LYC55716

LYC-55716 is novel oral RAR-related orphan receptor γ (RORγ) agonist.

Cat. No.

A16935

CAS No.

1802706-04-2

AGN-242428

Synonyms: VTP-43742

AGN-242428, also known as VTP-43742, is a potent, selective and orally active RORγt inhibitor for the treatment of autoimmune disorders, including multiple sclerosis and psoriasis.

Cat. No.

A17002

CAS No.

2102196-57-4

FAA1 agonist-1

FAA1 agonist-1 is a potent free fatty acid receptor 1 (FFA1/ GPR40) agonist with a pEC50 of 7.54.

Cat. No.

A18437

CAS No.

2349368-16-5

XY101

XY101 is a potent, selective, metabolically stable and orally available RORγ inverse agonist with an IC50 of 30 nM and a Kd of 380 nM.

Cat. No.

A18569

CAS No.

2361528-74-5

ROR agonist-1

ROR agonist-1 is a potent and orally bioavailable inverse agonist of the retinoic acid receptor-related orphan receptor C2 (RORC2), inhibition of IL-17A production from human primary TH 17 cells with a pIC50 of 7.5.

Cat. No.

A18766

CAS No.

2101291-07-8

AZD-0284

Synonyms: AZD0284.

AZD-0284 is a potent, selective, inverse agonist of the nuclear receptor RORγ for the potential treatment of Plaque psoriasis.

Cat. No.

A19078

CAS No.

2055271-22-0

A-9758

A-9758 is a RORγ ligand and a potent, selective RORγt inverse agonist (IC50=5 nM), and exhibits robust potency against IL-17A release.

Cat. No.

A19105

CAS No.

2068119-11-7

S18-000003

S18-000003 is a potent orally bioavailable retinoic acid receptor-related orphan receptor-gamma-t (RORγt) inhibitor with an IC50 of 29 nM. S18-000003 inhibits IL-17 production.

Cat. No.

A19605

CAS No.

1892576-58-7

PF-06747711

PF-06747711 is a potent, selective, and orally active retinoic acid receptor-related orphan C2 (RORC2, also known as RORγt) inverse agonist, with an IC50 of 4.1 nM. Anti-skin inflammatory activity.

Cat. No.

A19611

CAS No.

1854901-94-2

TAK-828F

TAK-828F is a potent, selective, and orally available retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonist (binding IC50=1.9 nM, reporter gene IC50=6.1 nM).

Cat. No.

A19996

CAS No.

1422171-08-1

(Rac)-TMP778

Synonyms: TMP 778??TMP-778

(Rac)-TMP778 is the racemate of TMP778. TMP778 is a potent and selevtive RORγt inverse agonist, with an IC50 of 7 nM in FRET assay.

Cat. No.

A20243

CAS No.

1801197-92-1

RORγt Inverse agonist 2

RORγt Inverse agonist 2 is a selective, orally active RORγt inverse agonist with an EC50 of 119 nM.

Cat. No.

A20344

CAS No.

20231-57-6

Methyl-3β-hydroxycholenate

Methyl-3β-hydroxycholenate is a ROR gamma modulator extracted from patent US20110263046 A1, in figure 2.

Cat. No.

A20422

CAS No.

303126-97-8

SR0987

SR0987, a SR1078 analog, is a RORγt agonist, with an EC50 of 800 nM. SR0987 increases IL17 expression while repressing the expression of PD-1.

Cat. No.

A20780

CAS No.

1677668-27-7

GNE-6468

GNE-6468 is a potent and selective RORγ(RORc) agonists with an EC50 value of 13 nM for HEK-293 cell.

Cat. No.

A20782

CAS No.

1677667-24-1

GNE-0946

GNE-0946 is a potent and selective RORγ( RORc) agonist with an EC50 value of 4 nM for HEK-293 cell.

Cat. No.

A22536

CAS No.

1422053-04-0

TMP778

Synonyms: TMP 778.

TMP778 is a novel, potent, and selective RORγt inverse agonist.

Cat. No.

A31512

CAS No.

2983540-55-0

W6134

W6134 is a potent and selective covalent inhibitor of RORγ, displaying an IC50 of 0.21 μM. This compound demonstrates remarkable selectivity for RORγ over RORα, RXRγ, and ERRγ. W6134 effectively suppresses RORγ transcriptional activity and has been shown to inhibit proliferation and colony formation while inducing apoptosis in castration-resistant prostate cancer (CRPC) cells. It is a valuable tool for investigating the mechanisms and treatment strategies for CRPC.

Cat. No.

A35962

CAS No.

2460133-35-9

BMS-986251

BMS-986251 is a selective RORγt inverse agonist with an EC50 of 12 nM in RORγt GAL4 assays. It effectively inhibits IL-17 production with an EC50 of 24 nM in human whole blood assays. BMS-986251 exhibits significant efficacy in preclinical models of psoriasis, including mouse acanthosis and Imiquimod-induced models, making it a valuable tool for research in autoimmune and inflammatory diseases.

Cat. No.

A38684

CAS No.

3000567-76-7

RORγ/DHODH-IN-1

RORγ/DHODH-IN-1 is a dual inhibitor targeting RORγ and dihydroorotate dehydrogenase (DHODH) with IC50 values of 9.7 nM and 100 nM, respectively. This compound effectively inhibits the replication of SARS-CoV-2, human cytomegalovirus (HCMV), and adenovirus type 5 (HAdV5), making it a valuable tool in viral research. Its dual mechanism of action allows for potential applications in understanding viral-pathogen interactions and developing therapeutic strategies against viral infections.