Fig. 1 · Structure
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8-Azanebularine
RNA-editing Inhibitor
8-Azanebularine is a novel RNA-editing inhibitor targeting the ADAR2 enzyme. This compound replaces the C6 amino group with hydrogen, leading to high-affinity binding to RNA structures recognized by human ADAR2, with a dissociation constant (KD) of 2 nM, and exhibits inhibition at high concentrations (IC50 = 15 mM). 8-Azanebularine is a valuable tool for investigating ADAR-catalyzed RNA-editing processes in various biological systems.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 38874-46-3 |
| Applications | RNA-editing Inhibitor |
| Formula | C9H11N5O4 |
| Molecular Weight | 253.21 |
| SMILES | O[C@H]1[C@](O[C@@H]([C@H]1O)CO)([H])N2C3=NC=NC=C3N=N2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.