Fig. 1 · Structure
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8-Br-7-CH-ADPR
Cat. No.
A68873
CAS
1011457-95-6
TRPM2 Antagonist
8-Br-7-CH-ADPR, a specific TRPM2 antagonist, effectively inhibits TRPM2 activation by binding to the NUDT9 homology domain of the TRPM2 channel. This modulation controls cation influx through the cell membrane, making it a valuable tool for investigating the physiological and pathological roles of TRPM2. Applications include studying cell death, neurodegenerative diseases, myocardial infarction, and diabetes, providing insights into TRPM2's involvement in various biological processes.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1011457-95-6 |
| Applications | TRPM2 Antagonist |
| Formula | C16H23BrN4O14P2 |
| Molecular Weight | 637.22 |
| Synonyms | 8-Bromo-7-deazaadenosine-5'-O-diphosphoribose |
| SMILES | O[C@H]1[C@@H](O)[C@H](N(C(Br)=C2)C3=C2C(N)=NC=N3)O[C@@H]1COP(OP(OC[C@@H]4[C@@H](O)[C@@H](O)C(O)O4)(O)=O)(O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.