8-M-PDOT is a selective agonist for the melatonin MT2 receptor, displaying a 5.2-fold preference for MT2 over MT1 receptors. It exhibits high binding affinity with human recombinant MT2 and MT1 receptors, demonstrating pKi values of 8.23 and 8.95, respectively. This compound exhibits anxiolytic-like properties, making it a valuable tool for research in sleep disorders and anxiety-related studies.
8-M-PDOT is a selective agonist for the melatonin MT2 receptor, displaying a 5.2-fold preference for MT2 over MT1 receptors. It exhibits high binding affinity with human recombinant MT2 and MT1 receptors, demonstrating pKi values of 8.23 and 8.95, respectively. This compound exhibits anxiolytic-like properties, making it a valuable tool for research in sleep disorders and anxiety-related studies.
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