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844-TFM

DNA Gyrase Inhibitor

844-TFM is a novel bacterial topoisomerase inhibitor that acts as a potent DNA gyrase inhibitor, exhibiting an IC50 of 1.5 μM. This compound demonstrates bactericidal activity specifically against Mycobacterium abscessus, making it a valuable tool for research in microbiology and antibiotic resistance mechanisms. Its unique properties position 844-TFM as a significant candidate for studies aimed at developing new treatments for bacterial infections.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2767443-97-8
Applications	DNA Gyrase Inhibitor
Formula	C₂₄H₂₅F₃N₄O₂
Molecular Weight	458.48
SMILES	COC1=CC=C2N=CC=C(C2=N1)NC(C3CCN(CC3)CCC4=CC=C(C=C4)C(F)(F)F)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.