Fig. 1 · Structure
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8RK59
UCHL1 Inhibitor
8RK59 is a potent inhibitor of UCHL1 (ubiquitin C-terminal hydrolase L1), exhibiting an IC50 value near 1 μM. This Bodipy probe is capable of penetrating and labeling living cells, making it valuable for cellular studies. The compound is synthesized via copper(I)-mediated click chemistry, which links BodipyFL-alkyne to the azide derivative of 8RK64, enhancing its utility in biological research and applications focused on ubiquitin pathway modulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2705841-53-6 |
| Applications | UCHL1 Inhibitor |
| Formula | C33H39BF2N10O2S |
| Molecular Weight | 688.60 |
| SMILES | O=C(N1CC2=C(N=C(S2)NC([C@@H]3CN(CC3)C#N)=O)CC1)CN(N=N4)C=C4CCCCC(C5=C(C)C=C(C)[N-]5[B+3]([F-])6[F-])=C7[N]6=C(C)C=C7C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.