Fig. 1 · Structure
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A-78773
Cat. No.
A76502
CAS
141579-67-1
5-lipoxygenase Inhibitor
A-78773 is a potent inhibitor of 5-lipoxygenase, demonstrating significant inhibition of leukotriene B4 (LTB4) production in human whole blood and neutrophils, with IC50 values of 85 nM and 20 nM, respectively. This compound is valuable for research into inflammation-related diseases, providing insights into leukotriene-mediated pathways and potential therapeutic interventions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 141579-67-1 |
| Applications | 5-lipoxygenase Inhibitor |
| Formula | C15H13FN2O4 |
| Molecular Weight | 304.27 |
| SMILES | O=C(N(O)C(C#CC1=CC=C(O1)OC2=CC=C(C=C2)F)C)N |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.