Fig. 1 · Structure
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α-Lipoic acid-NHS
PROTAC Linkers
α-Lipoic acid-NHS is a novel PROTAC linker featuring an alkyl/ether-based structure, designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the selective degradation of target proteins via the ubiquitin-proteasome system, making it valuable for cancer research and various therapeutic applications. Its unique properties enable efficient development of targeted protein degradation strategies in biological studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 40846-94-4 |
| Applications | PROTAC Linkers |
| Formula | C12H17NO4S2 |
| Molecular Weight | 303.40 |
| Synonyms | DL-α-Lipoic acid-NHS |
| SMILES | O=C(ON1C(CCC1=O)=O)CCCCC2SSCC2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.