α-Synuclein-IN-18 is a selective inhibitor of α-Synuclein aggregation, targeting the conserved binding pocket on α-synuclein fibrils. This compound effectively delays the autocatalytic proliferation of α-synuclein aggregates, extending the aggregation half-life by threefold. By reducing the generation of toxic α-synuclein oligomers, α-Synuclein-IN-18 offers potential in mitigating neurotoxicity associated with neurodegenerative diseases. Its application is particularly relevant in research related to Parkinson's disease.
α-Synuclein-IN-18 is a selective inhibitor of α-Synuclein aggregation, targeting the conserved binding pocket on α-synuclein fibrils. This compound effectively delays the autocatalytic proliferation of α-synuclein aggregates, extending the aggregation half-life by threefold. By reducing the generation of toxic α-synuclein oligomers, α-Synuclein-IN-18 offers potential in mitigating neurotoxicity associated with neurodegenerative diseases. Its application is particularly relevant in research related to Parkinson's disease.
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