a15:0-i15:0 PE is a diacyl phosphatidylethanolamine that functions as a non-canonical agonist for the TLR2-TLR1 heterodimer. It exhibits significant immunogenic activity, activating both T cells and dendritic cell signaling pathways while also demonstrating anti-inflammatory properties. a15:0-i15:0 PE promotes the production of pro-inflammatory cytokines such as TNFα and IL-6 and constitutes approximately 50% of the lipid membrane in A. muciniphila, highlighting its biological relevance in microbiome studies and immune response research.
a15:0-i15:0 PE is a diacyl phosphatidylethanolamine that functions as a non-canonical agonist for the TLR2-TLR1 heterodimer. It exhibits significant immunogenic activity, activating both T cells and dendritic cell signaling pathways while also demonstrating anti-inflammatory properties. a15:0-i15:0 PE promotes the production of pro-inflammatory cytokines such as TNFα and IL-6 and constitutes approximately 50% of the lipid membrane in A. muciniphila, highlighting its biological relevance in microbiome studies and immune response research.
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