a15:0-i15:0 PE

Catalog No.: A35354
TLR2-TLR1 Agonist
a15:0-i15:0 PE is a diacyl phosphatidylethanolamine that functions as a non-canonical agonist for the TLR2-TLR1 heterodimer. It exhibits significant immunogenic activity, activating both T cells and dendritic cell signaling pathways while also demonstrating anti-inflammatory properties. a15:0-i15:0 PE promotes the production of pro-inflammatory cytokines such as TNFα and IL-6 and constitutes approximately 50% of the lipid membrane in A. muciniphila, highlighting its biological relevance in microbiome studies and immune response research.
Grouped product items
Size Price Stock Qty
1mg
$620.00
In stock
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
Descriptiona15:0-i15:0 PE is a diacyl phosphatidylethanolamine that functions as a non-canonical agonist for the TLR2-TLR1 heterodimer. It exhibits significant immunogenic activity, activating both T cells and dendritic cell signaling pathways while also demonstrating anti-inflammatory properties. a15:0-i15:0 PE promotes the production of pro-inflammatory cytokines such as TNFα and IL-6 and constitutes approximately 50% of the lipid membrane in A. muciniphila, highlighting its biological relevance in microbiome studies and immune response research.
Product Information
Catalog NumA35354
FormulaC35H70NO8P
Molecular Weight663.91
CAS Number2936622-21-6
SMILESNCCOP(OC[C@H](OC(CCCCCCCCCCCC(C)C)=O)COC(CCCCCCCCCC[C@H](CC)C)=O)(O)=O
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