A2073 is a flavagline derivative that acts as a potent anti-erythroleukemia agent, primarily targeting the inhibition of cell proliferation in erythroleukemia cells. This compound induces cell cycle arrest and suppresses critical signaling pathways, including MAPK, NF-κB, and PI3K. A2073 engages in stable interactions with key cell cycle proteins such as CDK1, CCNA2, and PRIM1, demonstrating significant anti-proliferative efficacy against tumor cells while maintaining a favorable toxicity profile in zebrafish xenograft tumor models. This reagent is suitable for research applications focused on acute erythroleukemia.
A2073 is a flavagline derivative that acts as a potent anti-erythroleukemia agent, primarily targeting the inhibition of cell proliferation in erythroleukemia cells. This compound induces cell cycle arrest and suppresses critical signaling pathways, including MAPK, NF-κB, and PI3K. A2073 engages in stable interactions with key cell cycle proteins such as CDK1, CCNA2, and PRIM1, demonstrating significant anti-proliferative efficacy against tumor cells while maintaining a favorable toxicity profile in zebrafish xenograft tumor models. This reagent is suitable for research applications focused on acute erythroleukemia.
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