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$0.00 - Yi-Ru Pan, .et al. ATM Inhibitor Suppresses Gemcitabine-Resistant BTC Growth in a Polymerase θ Deficiency-Dependent Manner, Biomolecules, 2020, Nov 9;10(11):1529 PMID: 33182492
- Amnah Alshangiti, .et al. The dietary flavonoid isoliquiritigenin is a potent cytotoxin for human neuroblastoma cells, Neuronal Signal, 2019, 2019
- Calhelha RC, .et al. Mathematical models of cytotoxic effects in endpoint tumor cell line assays: critical assessment of the application of a single parametric value as a standard criterion to quantify the dose-response effects and new unexplored proposal formats, Analyst, 2017, Oct 23;142(21):4124-4141 PMID: 28991301
- Pi-Lin Sung, .et al. Periostin in tumor microenvironment is associated with poor prognosis and platinum resistance in epithelial ovarian carcinoma, Oncotarget, 2016, Jan 26; 7(4): 4036-4047 PMID: 26716408 >
Biological Activity
Cisplatin was the first member of a class of platinum-containing anti-cancer drugs, which now also includes carboplatin and oxaliplatin. These platinum complexes react in vivo, binding to and causing crosslinking of DNA, which ultimately triggers apoptosis (programmed cell death).
Targets
| DNA synthesis (Tumor cells) | ||||
| In vitro | DMSO | 56 mg/mL (186.63 mM) | |
| Water | DMF: 11 mg/mL (36.66 mM) | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 33.32 mL | 166.61 mL | 333.22 mL |
| 0.5 mM | 6.66 mL | 33.32 mL | 66.64 mL |
| 1 mM | 3.33 mL | 16.66 mL | 33.32 mL |
| 5 mM | 0.67 mL | 3.33 mL | 6.66 mL |
*The above data is based on the productmolecular weight 300.1. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10221 |
|---|---|
| CAS No. | 15663-27-1 |
| Formula | Cl2H4N2Pt |
| M. Wt | 300.1 |
| Purity | >98% |
| Synonyms | cisplatinum, CDDP, cis-diamminedichloroplatinum(II) |
| SMILES | N.N.Cl[Pt+2]Cl |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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