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Cisplatin

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Catalog No. A10221

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Cisplatin 250mg A10221-250

Regular Price: $60.00

Special Price: $54.00

Cisplatin 2g A10221-2000

Regular Price: $400.00

Special Price: $360.00

Cisplatin 10mM * 1mL in DMSO A10221-10mM-D

Regular Price: $60.00

Special Price: $54.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Cisplatin was the first member of a class of platinum-containing anti-cancer drugs, which now also includes carboplatin and oxaliplatin. These platinum complexes react in vivo, binding to and causing crosslinking of DNA, which ultimately triggers apoptosis (programmed cell death).

Cisplatin

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Publications citing Adooq Products
Cisplatin Citations (3)
  • Amnah Alshangiti, .et al. The dietary flavonoid isoliquiritigenin is a potent cytotoxin for human neuroblastoma cells, Neuronal Signal, 2019, 2019
  • Calhelha RC, .et al. Mathematical models of cytotoxic effects in endpoint tumor cell line assays: critical assessment of the application of a single parametric value as a standard criterion to quantify the dose-response effects and new unexplored proposal formats, Analyst, 2017, Oct 23;142(21):4124-4141 PMID: 28991301
  • Pi-Lin Sung, .et al. Periostin in tumor microenvironment is associated with poor prognosis and platinum resistance in epithelial ovarian carcinoma, Oncotarget, 2016, Jan 26; 7(4): 4036-4047 PMID: 26716408

Chemical Information

Catalog Num A10221
Actions N/A
M. Wt 300.1
Formula Cl2H4N2Pt
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 15663-27-1
Synonyms cisplatinum, CDDP, cis-diamminedichloroplatinum(II)
SMILES N.N.Cl[Pt+2]Cl

Biological Activity

Description
Cisplatin was the first member of a class of platinum-containing anti-cancer drugs, which now also includes carboplatin and oxaliplatin. These platinum complexes react in vivo, binding to and causing crosslinking of DNA, which ultimately triggers apoptosis (programmed cell death).
Targets
DNA synthesis (Tumor cells)

Solubility

Solubility (25°C)* In vitro DMSO 60 mg/mL (199.96 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 33.32 mL 166.61 mL 333.22mL
0.5 mM 6.66 mL 33.32 mL 66.64 mL
1 mM 3.33 mL 16.66 mL 33.32 mL
5 mM 0.67 mL 3.33 mL 6.66 mL

*The above data is based on the productmolecular weight 300.1. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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