Fig. 1 · Structure
Documents & Downloads
AA-CW236
MGMT Inhibitor
AA-CW236 is an inhibitor of MGMT (O6-methylguanine DNA methyltransferase), specifically targeting the active site cysteine residue Cys145 for covalent modification. This compound effectively impedes the DNA repair function of MGMT, which plays a crucial role in the repair of alkylated DNA. Due to its mechanism of action, AA-CW236 is valuable in research applications focused on enhancing the efficacy of alkylating agents in cancer treatment and studying DNA repair pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1869921-96-9 |
| Applications | MGMT Inhibitor |
| Formula | C17H16ClF3N4O2 |
| Molecular Weight | 400.78 |
| SMILES | FC(F)(F)OC1=CC=C(C2=C(CCl)N(CCC3=C(C)ON=C3C)N=N2)C=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.