AA863 is a selective inhibitor of 5-lipoxygenase, which plays a crucial role in the metabolism of arachidonic acid and the production of leukotrienes. This compound demonstrates significant dose-dependent inhibition of human glioma cell proliferation, with an IC50 value of 9.0 micromolar in monolayer cultures. AA863 is a valuable tool for researchers investigating glioma biology and the therapeutic potential of targeting lipoxygenase pathways.
AA863 is a selective inhibitor of 5-lipoxygenase, which plays a crucial role in the metabolism of arachidonic acid and the production of leukotrienes. This compound demonstrates significant dose-dependent inhibition of human glioma cell proliferation, with an IC50 value of 9.0 micromolar in monolayer cultures. AA863 is a valuable tool for researchers investigating glioma biology and the therapeutic potential of targeting lipoxygenase pathways.
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