Fig. 1 · Structure
Documents & Downloads
AA9
TG2 Inhibitor
AA9 is a potent inhibitor of Transglutaminase 2 (TG2), a crucial enzyme involved in various cellular processes, including extracellular matrix remodeling and cell signaling. This compound demonstrated a significant effect on HIF-mediated hypoxia in MDA-MB-231 cells, suggesting its potential utility in cancer research, particularly in studying the mechanisms of tumor hypoxia and metastatic behavior. AA9 can be utilized in experiments investigating TG2's role in various pathological conditions and therapeutic contexts.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2134114-20-6 |
| Applications | TG2 Inhibitor |
| Formula | C32H36N4O5 |
| Molecular Weight | 556.65 |
| SMILES | O=C(OCC1=CC=CC=C1)N[C@H](C(N2CCN(C(C3=C4C=CC=CC4=CC=C3)=O)CC2)=O)CCCCNC(C=C)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.