AAT-008 is a selective and orally active antagonist of the prostaglandin EP4 receptor, exhibiting Ki values of 0.97 nM for recombinant human EP4 and 6.1 nM for recombinant rat EP4. This compound demonstrates significant tumor growth delay in murine models of CT26WT colon tumors when used in conjunction with radiotherapy. AAT-008 is valuable for investigating acute and chronic inflammatory pain, as well as cancer-related research applications.
AAT-008 is a selective and orally active antagonist of the prostaglandin EP4 receptor, exhibiting Ki values of 0.97 nM for recombinant human EP4 and 6.1 nM for recombinant rat EP4. This compound demonstrates significant tumor growth delay in murine models of CT26WT colon tumors when used in conjunction with radiotherapy. AAT-008 is valuable for investigating acute and chronic inflammatory pain, as well as cancer-related research applications.
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