Fig. 1 · Structure
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AAT-008
EP4 Receptor Antagonist
AAT-008 is a selective and orally active antagonist of the prostaglandin EP4 receptor, exhibiting Ki values of 0.97 nM for recombinant human EP4 and 6.1 nM for recombinant rat EP4. This compound demonstrates significant tumor growth delay in murine models of CT26WT colon tumors when used in conjunction with radiotherapy. AAT-008 is valuable for investigating acute and chronic inflammatory pain, as well as cancer-related research applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 847727-81-5 |
| Applications | EP4 Receptor Antagonist |
| Formula | C21H16ClFN2O4 |
| Molecular Weight | 414.81 |
| SMILES | O=C(O)C1=CC=C([C@@H](NC(C2=CC(Cl)=CN=C2OC3=CC=CC(F)=C3)=O)C)C=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.