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AB1

S1P2 Receptor Antagonist

AB1 is a highly selective antagonist of the sphingosine-1-phosphate receptor 2 (S1P2) with an IC50 of 3.5 nM. It effectively inhibits S1P signaling pathways, leading to the suppression of tumor cell migration, angiogenesis, and the expression of the profibrotic mediator CTGF, while promoting apoptosis in cancer cells. This compound demonstrates significant potential for research focused on solid tumors and their microenvironment.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	1463912-49-3
Applications	S1P2 Receptor Antagonist
Formula	C₁₉H₂₁Cl₂N₇O
Molecular Weight	434.32
SMILES	C=CCN1N=C(C)C2=C(C(C)C)C=C(NNC(NC3=CC(Cl)=NC(Cl)=C3)=O)N=C21

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.