Fig. 1 · Structure
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AB182
DNA/RNA Synthesi
AB182 is an aziridine derivative with potent antitumor activity that targets DNA/RNA synthesis. It exhibits synergistic effects when used in conjunction with x-irradiation by inhibiting DNA repair mechanisms. The hydrolysis products of AB182 may phosphorylate the free 3'-OH end groups of DNA strands, effectively blocking repair of x-irradiation-induced breaks. This compound holds promise for enhancing therapeutic efficacy in cancer treatment research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 54805-58-2 |
| Applications | DNA/RNA Synthesi |
| Formula | C11H22N3O4P |
| Molecular Weight | 291.28 |
| SMILES | O=C(NOP(N1C(C)(C1)C)(N2C(C)(C2)C)=O)OCC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.