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Abituzumab

Abituzumab (DI17E6) is a humanized monoclonal antibody of the IgG2 subtype that targets integrin αV. It effectively inhibits the phosphorylation of focal adhesion kinase (FAK), Akt, and extracellular signal-regulated kinase (ERK), key signaling molecules involved in cell migration and survival. This antibody is particularly useful in cancer research applications, with a focus on studies related to prostate cancer. Abituzumab's precise targeting of integrin αV makes it a valuable tool for investigating the role of this integrin in tumor progression and metastasis.

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Biological Activity

Target & Activity

Integrin αV.

Product Details

Manufacturer Adooq Bioscience
CAS Number 1105038-73-0
Molecular Weight 144580
Synonyms EMD 525797; DI17E6

Storage

Store lyophilized at -20°C, keep desiccated.
In lyophilized form, the antibody is stable for 36 months.
After reconstitution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Customer Questions
Biosimilar antibodies are research-grade recombinant antibodies designed to closely resemble approved therapeutic antibodies in terms of amino acid sequence, structural characteristics, and biological activity. These antibodies are generated using recombinant expression technologies and retain the same variable regions as their corresponding reference therapeutics, thereby preserving target specificity and binding affinity. Owing to these properties, biosimilar antibodies serve as reliable and cost-effective research reagents for applications in drug discovery, pharmacological studies, and basic biomedical research. Research-grade biosimilar antibodies have been successfully expressed and functionally validated against a wide range of widely studied targets. These antibodies can be directly utilized as positive control reagents in drug discovery programs, as well as reference tools for rapid verification of the biological functions of target proteins in biochemical and cellular assays.
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