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Abituzumab
Abituzumab (DI17E6) is a humanized monoclonal antibody of the IgG2 subtype that targets integrin αV. It effectively inhibits the phosphorylation of focal adhesion kinase (FAK), Akt, and extracellular signal-regulated kinase (ERK), key signaling molecules involved in cell migration and survival. This antibody is particularly useful in cancer research applications, with a focus on studies related to prostate cancer. Abituzumab's precise targeting of integrin αV makes it a valuable tool for investigating the role of this integrin in tumor progression and metastasis.
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Biological Activity
Product Details
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1105038-73-0 |
| Molecular Weight | 144580 |
| Synonyms | EMD 525797; DI17E6 |
Storage
Store lyophilized at -20°C, keep desiccated.
In lyophilized form, the antibody is stable for 36 months.
After reconstitution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.