Fig. 1 · Structure
Documents & Downloads
ABT-100
Farnesyltransferase Inhibitor
ABT-100 is a potent and selective farnesyltransferase inhibitor that exerts its effects on cellular proliferation and survival. With IC50 values ranging from 2.2 nM to 818 nM across various cancer cell lines, such as EJ-1, DLD-1, and MDA-MB-231, ABT-100 significantly enhances apoptosis while inhibiting angiogenesis. This compound showcases broad-spectrum antitumor activity, making it a valuable tool for cancer research and therapeutic studies targeting farnesyltransferase pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 450839-40-4 |
| Applications | Farnesyltransferase Inhibitor |
| Formula | C27H19F3N4O3 |
| Molecular Weight | 504.46 |
| SMILES | N#CC1=CC(C2=CC=C(OC(F)(F)F)C=C2)=C(OC[C@](O)(C3=CC=C(C#N)C=C3)C4=CN=CN4C)C=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.