Fig. 1 · Structure
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ABT-702 hydrochloride
Adenosine Kinase Inhibitor
ABT-702 hydrochloride is a selective adenosine kinase (AK) inhibitor, exhibiting an IC50 of 1.7 nM. With over 1300-fold selectivity for AK compared to other biological targets, including cyclooxygenases-1 and -2, ABT-702 hydrochloride effectively increases free adenosine levels, thereby attenuating inflammation associated with diabetic retinopathy. Additionally, it demonstrates both analgesic and anti-inflammatory properties in vivo, making it a valuable reagent for research in diabetic retinopathy and related conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2624336-92-9 |
| Applications | Adenosine Kinase Inhibitor |
| Formula | C22H20BrClN6O |
| Molecular Weight | 499.79 |
| SMILES | NC1=C(C(C2=CC=CC(Br)=C2)=CC(C3=CC=C(N4CCOCC4)N=C3)=N5)C5=NC=N1.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.