Fig. 1 · Structure
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ABT-770
MMP2 Inhibitor
ABT-770 is a selective and orally active inhibitor of matrix metalloproteinase 2 (MMP-2), exhibiting over 1000-fold selectivity with an IC50 of 4 nM compared to MMP-1 (IC50 = 4600 nM). This compound is valuable for research into tumor biology, particularly in studies focused on tumor growth, invasion, and metastasis, providing insights into the role of MMP-2 in cancer progression.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 220614-50-6 |
| Applications | MMP2 Inhibitor |
| Formula | C22H22F3N3O6 |
| Molecular Weight | 481.42 |
| SMILES | O=CN([C@@H](CN(C(NC1(C)C)=O)C1=O)COC2=CC=C(C3=CC=C(OC(F)(F)F)C=C3)C=C2)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.