Fig. 1 · Structure
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Ac-DEVD-pNA
Colorimetric Substrate
Ac-DEVD-pNA is a colorimetric substrate specifically designed for the detection of caspase-3 and caspase-7 activity, serving as a critical tool in apoptosis research. This substrate is cleaved by these cysteine proteases, leading to the release of a chromogenic product that can be quantitatively measured. It is widely used in studies investigating programmed cell death and in drug discovery efforts targeting apoptotic pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 189950-66-1 |
| Applications | Colorimetric Substrate |
| Formula | C26H34N6O13 |
| Molecular Weight | 638.58 |
| SMILES | CC(C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(C)=O)C(=O)N([C@@H](CC(N)=O)C(O)=O)c1ccc(cc1)[N+]([O-])=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.