(Ac)Phe-Lys(Alloc)-PABC-PNP

Catalog No.: A43453
ADC Linker
(Ac)Phe-Lys(Alloc)-PABC-PNP is a cleavable chemical linker designed for use in antibody-drug conjugates (ADCs). It facilitates targeted delivery of therapeutic agents by linking the antibody to the drug while ensuring controlled release upon reaching the target site. This linker is valuable in the development of ADCs, enhancing their efficacy and minimizing off-target effects in cancer research and therapy.
Grouped product items
Size Stock
5mg
10mg
50mg
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

Loading distributor info...

Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
Description(Ac)Phe-Lys(Alloc)-PABC-PNP is a cleavable chemical linker designed for use in antibody-drug conjugates (ADCs). It facilitates targeted delivery of therapeutic agents by linking the antibody to the drug while ensuring controlled release upon reaching the target site. This linker is valuable in the development of ADCs, enhancing their efficacy and minimizing off-target effects in cancer research and therapy.
Product Information
Catalog NumA43453
FormulaC35H39N5O10
Molecular Weight689.71
CAS Number2070009-39-9
SMILESO=C(C)N[C@H](C(N[C@@H](CCCCNC(OCC=C)=O)C(NC1=CC=C(COC(OC2=CC=C([N+]([O-])=O)C=C2)=O)C=C1)=O)=O)CC3=CC=CC=C3
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass

    Concentration

    Volume

    Molecular Weight

Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

  • C1

    V1

    C2

    V2