ACBI1

Name: ACBI1
Brand: Adooq Bioscience
SKU: A23919
Rating: 5 (288 reviews)

Catalog No.: A23919

SMARCA2/SMARCA4/PBRM1 Degrader

ACBI1 is a potent and cooperative PROTAC degrader targeting SMARCA2, SMARCA4, and PBRM1, with DC₅₀ values of 6 nM, 11 nM, and 32 nM, respectively. It exhibits strong anti-proliferative activity and induces apoptosis, making it a valuable tool for studying chromatin remodeling and cancer therapeutics.

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ACBI1 2375564-55-7 SMARCA2/SMARCA4/PBRM1 Degrader

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Grouped product items
Size	Price	Stock
5mg	$275.00	In stock
10mg	$420.00	In stock
50mg	$1,020.00	In stock
100mg	$1,580.00	In stock
Bulk Size	Bulk Discount

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Research use only. We do not sell to patients.

Data Sheet SDS

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Adooq Products cited in reputable paper

Biological Activity

Description	ACBI1 is a potent and cooperative PROTAC degrader targeting SMARCA2, SMARCA4, and PBRM1, with DC₅₀ values of 6 nM, 11 nM, and 32 nM, respectively. It exhibits strong anti-proliferative activity and induces apoptosis, making it a valuable tool for studying chromatin remodeling and cancer therapeutics.

Product Information

Catalog Num	A23919
Formula	C49H58FN9O7S
Molecular Weight	936.10
CAS Number	2375564-55-7
SMILES	CC(N=CS1)=C1C2=CC=C(CNC([C@@H]3C[C@@H](O)CN3C([C@H](C(C)(C)C)NC(C4(CC4)F)=O)=O)=O)C(OCCOC5=CC=C(CN6CCN(C7=CC(C8=C(O)C=CC=C8)=NN=C7N)CC6)C=C5)=C2
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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