PROTAC SMARCA2/4-degrader-28 is a PROTAC (Proteolysis Targeting Chimeras) designed to target and degrade SMARCA2 and SMARCA4 proteins. This compound utilizes a combination of a CRL2VHL ligand, a linker, and a SMARCA-BD ligand to facilitate targeted degradation, thus modulating the expression of these critical chromatin remodeling factors. Its primary applications include studying the functional roles of SMARCA2 and SMARCA4 in cancer biology and epigenetic regulation, making it a valuable tool for researchers investigating therapeutic strategies in oncology and related fields.
PROTAC SMARCA2/4-degrader-28 is a PROTAC (Proteolysis Targeting Chimeras) designed to target and degrade SMARCA2 and SMARCA4 proteins. This compound utilizes a combination of a CRL2VHL ligand, a linker, and a SMARCA-BD ligand to facilitate targeted degradation, thus modulating the expression of these critical chromatin remodeling factors. Its primary applications include studying the functional roles of SMARCA2 and SMARCA4 in cancer biology and epigenetic regulation, making it a valuable tool for researchers investigating therapeutic strategies in oncology and related fields.
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