AChE-IN-6 is a potent acetylcholinesterase (AChE) inhibitor, exhibiting significant inhibitory activity against both eel AChE (IC50 = 0.20 μM) and human AChE (IC50 = 37.02 nM). Additionally, AChE-IN-6 demonstrates robust anti-amyloid beta activity, with IC50 values of 1.92 μM for inhibiting self-induced Aβ1-42 aggregation and 1.80 μM for promoting disaggregation of Aβ1-42 fibrils. These properties suggest its utility in Alzheimer's disease research, particularly in exploring therapeutic strategies targeting cholinergic dysfunction and amyloid pathology.
AChE-IN-6 is a potent acetylcholinesterase (AChE) inhibitor, exhibiting significant inhibitory activity against both eel AChE (IC50 = 0.20 μM) and human AChE (IC50 = 37.02 nM). Additionally, AChE-IN-6 demonstrates robust anti-amyloid beta activity, with IC50 values of 1.92 μM for inhibiting self-induced Aβ1-42 aggregation and 1.80 μM for promoting disaggregation of Aβ1-42 fibrils. These properties suggest its utility in Alzheimer's disease research, particularly in exploring therapeutic strategies targeting cholinergic dysfunction and amyloid pathology.
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