Fig. 1 · Structure
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AChE-IN-7
AChE Inhibitor
AChE-IN-7 is a highly selective and potent inhibitor of acetylcholinesterase with an eeAChE IC50 value of 0.045 μM and an eeBuChE IC50 of 19.68 μM. This compound demonstrates promising in vivo and in vitro safety profiles, along with favorable pharmacokinetic characteristics and high bioavailability (F = 55.5%). Additionally, AChE-IN-7 exhibits significant permeability across the blood-brain barrier, making it a valuable tool for research into neurological disorders and therapeutic strategies targeting cholinergic signaling.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2699090-78-1 |
| Applications | AChE Inhibitor |
| Formula | C26H28N2O2 |
| Molecular Weight | 400.51 |
| SMILES | O=C1C2=C(C3=NC=CC4=CC(OCCCCN5CCCCC5C)=CC1=C43)C=CC=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.