Fig. 1 · Structure
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Adenosylcobalamin
Coenzyme
Adenosylcobalamin (Coenzyme B12; Cobamamide; AdoCbl) is the biologically active form of Vitamin B12, serving as a crucial cofactor for methylmalonyl CoA mutase. This enzyme plays a significant role in the metabolism of certain amino acids and fatty acids, facilitating the conversion of methylmalonyl CoA to succinyl CoA. It is particularly valuable in studies related to metabolic disorders and vitamin B12 deficiency. Research applications include enzymatic assays and investigations into metabolic pathways involving branched-chain amino acids.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 13870-90-1 |
| Applications | Coenzyme |
| Formula | C72H100CoN18O17P |
| Molecular Weight | 1579.58 |
| Synonyms | Coenzyme B12; Cobamamide; AdoCbl |
| SMILES | O[C@@H]1[C@H](O[C@@H](N2C3=NC=NC(N)=C3N=C2)[C@@H]1O)[CH2-][Co+3]456([N]7=CN([C@@H](O[C@H](CO)[C@H]8OP9([O-])=O)[C@]8([H])O)C%10=CC(C)=C(C)C=C7%10)[N]%11=C%12[C@@H](CCC(N)=O)[C@@](CC(N)=O)(C)[C@]%11(C)[C@]([C@H](CC(N)=O)[C@]%13(CCC(NC[C@@H](C)O9)=O)C)([H])[N-]4C%13=C(C)C([C@@H](CCC(N)=O)C%14(C)C)=[N]5C%14=CC%15=[N]6C([C@](CC(N)=O)(C)[C@@H]%15CCC(N)=O)=C%12C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.