Fig. 1 · Structure
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Aderamastat
MMP-12 Inhibitor
Aderamastat is a selective inhibitor of MMP-12, providing a targeted approach to modulating extracellular matrix remodeling. This compound demonstrates protective effects against house dust mite-sensitized allergic asthma and is valuable in the study of respiratory diseases, such as chronic inflammatory airway conditions and pulmonary fibrosis. Its selectivity and oral bioavailability make it an important tool for exploring therapeutic interventions in related pathologies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 877176-23-3 |
| Applications | MMP-12 Inhibitor |
| Formula | C21H18N2O4S |
| Molecular Weight | 394.44 |
| Synonyms | FP-025 |
| SMILES | O=C1NC(C(C2=C(SC3=CC=C(C=C3)OCC4=CC(C)=CC=C4)C=CO2)N1)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.