(+)-Adlumidine is an isoquinoline alkaloid that acts as a potent inhibitor of SARS-CoV-2 by targeting the main protease (Mpro) and the receptor-binding domain (RBD) with IC50 values of 953.86 μM and 9.48 μM, respectively. This compound exhibits notable positive inotropic and positive chronotropic effects on cultured mouse embryonic cardiomyocytes. Additionally, (+)-Adlumidine is useful for research focused on cardiovascular diseases and mechanisms of SARS-CoV-2 infection.
(+)-Adlumidine is an isoquinoline alkaloid that acts as a potent inhibitor of SARS-CoV-2 by targeting the main protease (Mpro) and the receptor-binding domain (RBD) with IC50 values of 953.86 μM and 9.48 μM, respectively. This compound exhibits notable positive inotropic and positive chronotropic effects on cultured mouse embryonic cardiomyocytes. Additionally, (+)-Adlumidine is useful for research focused on cardiovascular diseases and mechanisms of SARS-CoV-2 infection.
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