Fig. 1 · Structure
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AF-2112
TEAD Inhibitor
AF-2112 is a TEAD inhibitor derived from Flufenamic acid, known to significantly reduce the expression of connective tissue growth factor (CTGF), cysteine-rich protein (Cyr61), axl receptor tyrosine kinase (Axl), and neurofibromin 2 (NF2). This compound serves as a valuable research tool for studies investigating the Hippo signaling pathway and its role in cellular growth, proliferation, and cancer biology. AF-2112's ability to modulate TEAD activity makes it suitable for exploring therapeutic strategies targeting TEAD-dependent gene expression.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2996821-62-4 |
| Applications | TEAD Inhibitor |
| Formula | C21H18FNO3 |
| Molecular Weight | 351.37 |
| SMILES | OC(C1=CC=C(F)C=C1NC2=CC(OCCC3=CC=CC=C3)=CC=C2)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.