AF3485 is an inhibitor of the human microsomal prostaglandin E synthase-1 (mPGES-1), demonstrating significant antitumor activity both in vitro and in vivo. This compound effectively targets tumor-associated angiogenesis by lowering prostaglandin E2 (PGE2) levels, inhibiting epidermal growth factor receptor (EGFR) signaling, and decreasing the expression of vascular endothelial growth factor (VEGF) and fibroblast growth factor-2 (FGF-2). Subchronic administration of AF3485 has been shown to reduce tumor growth in mice with human A431 xenograft tumors, making it a valuable tool for cancer research.
AF3485 is an inhibitor of the human microsomal prostaglandin E synthase-1 (mPGES-1), demonstrating significant antitumor activity both in vitro and in vivo. This compound effectively targets tumor-associated angiogenesis by lowering prostaglandin E2 (PGE2) levels, inhibiting epidermal growth factor receptor (EGFR) signaling, and decreasing the expression of vascular endothelial growth factor (VEGF) and fibroblast growth factor-2 (FGF-2). Subchronic administration of AF3485 has been shown to reduce tumor growth in mice with human A431 xenograft tumors, making it a valuable tool for cancer research.
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