Fig. 1 · Structure
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Afeletecan hydrochloride
Ester Prodrug
Afeletecan hydrochloride is an ester prodrug designed to facilitate the delivery of the active drug form. Its primary mechanism involves conversion to an active topoisomerase I inhibitor, which disrupts DNA replication and transcription, leading to cancer cell apoptosis. This compound is primarily utilized in cancer research, particularly in studies focused on therapeutic strategies for various malignancies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 215604-74-3 |
| Applications | Ester Prodrug |
| Formula | C45H50ClN7O11S |
| Molecular Weight | 932.44 |
| Synonyms | BAY 56-3722; BAY 38-3441 |
| SMILES | O[C@@H]([C@@H]([C@@H]([C@@H](O1)C)O)OC)[C@H]1OC(C=C2)=CC=C2NC(N[C@@H](CC3=CN=CN3)C(N[C@@H](C(C)C)C(O[C@]4(C5=C(COC4=O)C(N6C(C7=NC8=CC=CC=C8C=C7C6)=C5)=O)CC)=O)=O)=S.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.