Fig. 1 · Structure
Documents & Downloads
Afoxolaner
Isoxazoline Insecticide/Acaricide
Afoxolaner is an orally active isoxazoline insecticide and acaricide targeting Ixodes scapularis in dogs. It functions through the modulation of insect γ-aminobutyric acid (GABA) receptors and glutamate receptors, leading to inhibition of GABA and glutamate-regulated chloride ion uptake. This mechanism results in heightened neuronal stimulation and ultimately causes the mortality of the arthropod. Afoxolaner is utilized in research concerning ectoparasite control and the management of tick-borne diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1093861-60-9 |
| Applications | Isoxazoline Insecticide/Acaricide |
| Formula | C26H17ClF9N3O3 |
| Molecular Weight | 625.87 |
| SMILES | O=C(C1=C2C=CC=CC2=C(C3=NOC(C(F)(F)F)(C4=CC(C(F)(F)F)=CC(Cl)=C4)C3)C=C1)NCC(NCC(F)(F)F)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.