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AG 490 is a selective inhibitor of EGF receptor tyrosine kinase (IC50 values are 2 and 13.5 μM for EGFR and ErbB2 respectively). Also inhibits JAK2 with no activity to Lck, Lyn, Btk, Syk and Src.
Targets
| EGFR (Cell-free assay) | JAK2 (Cell-free assay) | ErbB2 (Cell-free assay) | ||
| 0.1 μM | ~10 μM | 13.5 μM |
| In vitro (25°C) | DMSO | 59 mg/mL (200.47 mM) | |
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | 6 mg/mL (20.38 mM) | ||
| In vivo | 1% DMSO/30% polyethylene glycol/1% Tween 80 | 30 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 33.98 mL | 169.89 mL | 339.79 mL |
| 0.5 mM | 6.8 mL | 33.98 mL | 67.96 mL |
| 1 mM | 3.4 mL | 16.99 mL | 33.98 mL |
| 5 mM | 0.68 mL | 3.4 mL | 6.8 mL |
*The above data is based on the productmolecular weight 294.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Technical Details
| Catalog Num | A10047 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 294.3 |
| Formula | C17H14N2O3 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 133550-30-8 |
| Synonyms | Tyrphostin AG490 |
| SMILES | C1=CC=C(C=C1)CNC(=O)/C(=C/C2=CC(=C(C=C2)O)O)/C#N |
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