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AG-490

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EGFR inhibitor

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Catalog No. A10047

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
AG-490 10mg A10047-10

Regular Price: €28.50

Special Price: €25.65

AG-490 50mg A10047-50

Regular Price: €76.00

Special Price: €68.40

AG-490 100mg A10047-100

Regular Price: €104.50

Special Price: €94.05

AG-490 200mg A10047-200

Regular Price: €190.00

Special Price: €171.00

AG-490 10mM * 1mL in DMSO A10047-10mM-D

Regular Price: €64.60

Special Price: €58.14

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

AG 490 is a selective inhibitor of EGF receptor tyrosine kinase (IC50 values are 2 and 13.5 μM for EGFR and ErbB2 respectively). Also inhibits JAK2 with no activity to Lck, Lyn, Btk, Syk and Src.

AG-490

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Publications citing Adooq Products
AG-490 Citations (1)
  • Matozaki M, .et al. Involvement of Stat3 phosphorylation in mild heat shock-induced thermotolerance, Exp Cell Res, 2019, Feb 15. pii: S0014-4827(18)31030-9 PMID: 30776355

Chemical Information

Catalog Num A10047
Actions Inhibitor
M. Wt 294.3
Formula C17H14N2O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 133550-30-8
Synonyms Tyrphostin AG490
SMILES C1=CC=C(C=C1)CNC(=O)/C(=C/C2=CC(=C(C=C2)O)O)/C#N

Biological Activity

Description
 AG 490 is a selective inhibitor of EGF receptor tyrosine kinase (IC50 values are 2 and 13.5 μM for EGFR and ErbB2 respectively). Also inhibits JAK2 with no activity to Lck, Lyn, Btk, Syk and Src.
Targets
EGFR (Cell-free assay) JAK2 (Cell-free assay) ErbB2 (Cell-free assay)
0.1 μM~10 μM13.5 μM

Solubility

Solubility (25°C) * In vitro DMSO 59 mg/mL (200.47 mM)
Water <1 mg/mL (<1 mM)
Ethanol 6 mg/mL (20.38 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 33.98 mL 169.89 mL 339.79mL
0.5 mM 6.8 mL 33.98 mL 67.96 mL
1 mM 3.4 mL 16.99 mL 33.98 mL
5 mM 0.68 mL 3.4 mL 6.8 mL

*The above data is based on the productmolecular weight 294.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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WaterDMSOEthanol
A10043 AEE788 <1 mg/mL 88 mg/mL <1 mg/mL
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A11158 ARRY334543 <1 mg/mL 6 mg/mL <1 mg/mL
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A11209 Lenalidomide (CC-5013) <1 mg/mL 113 mg/mL 20 mg/mL
A10743 BMS 599626 (AC480) <1 mg/mL 55 mg/mL <1 mg/mL
A10211 Canertinib (CI-1033) <1 mg/mL 2 mg/mL 9 mg/mL
A10210 Chrysophanic acid (Chrysophanol) <1 mg/mL <1 mg/mL <1 mg/mL
A10242 CP-724714 <1 mg/mL 94 mg/mL 94 mg/mL
A10362 Erlotinib hydrochloride <1 mg/mL 3 mg/mL <1 mg/mL
A10422 Gefitinib (Iressa) <1 mg/mL 89 mg/mL 4 mg/mL
A10514 Lapatinib Ditosylate <1 mg/mL 185 mg/mL <1 mg/mL
A10612 Mubritinib (TAK 165) 13 mg/mL <1 mg/mL <1 mg/mL
A10638 Neratinib (HKI-272) 2 mg/mL <1 mg/mL <1 mg/mL
A10678 OSI-420 83 mg/mL 2 mg/mL <1 mg/mL
A10702 PD153035 (HCl salt) <1 mg/mL <1 mg/mL <1 mg/mL
A10706 Pelitinib (EKB-569) <1 mg/mL 13 mg/mL <1 mg/mL
A11051 PF299804 <1 mg/mL 19 mg/mL <1 mg/mL
A11236 TAK-285 <1 mg/mL 110 mg/mL 54 mg/mL
A10053 Tyrphostin AG 879 36 mg/mLtd <1 mg/mL 3 mg/mL
A10990 WZ3146 <1 mg/mL 93 mg/mL <1 mg/mL
A10991 WZ4002 13 mg/mL <1 mg/mL <1 mg/mL
A10992 WZ8040 96 mg/mL <1 mg/mL 3 mg/mL

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