AG-490

Catalog No.: A10047

EGFR inhibitor

AG-490 Chemical Structure

CAS NO. 133550-30-8

AG 490 is a selective inhibitor of EGF receptor tyrosine kinase (IC50 values are 2 and 13.5 μM for EGFR and ErbB2 respectively). Also inhibits JAK2 with no activity to Lck, Lyn, Btk, Syk and Src.

Availability: In stock

Package Price Qty
10 mg
$30.00
50 mg
$80.00
100 mg
$110.00
200 mg
$200.00
10mM * 1mL in DMSO
$68.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

AG 490 is a selective inhibitor of EGF receptor tyrosine kinase (IC50 values are 2 and 13.5 μM for EGFR and ErbB2 respectively). Also inhibits JAK2 with no activity to Lck, Lyn, Btk, Syk and Src.
Targets
EGFR (Cell-free assay) JAK2 (Cell-free assay) ErbB2 (Cell-free assay)
0.1 μM~10 μM13.5 μM
In vitro (25°C) DMSO 59 mg/mL (200.47 mM)
Water <1 mg/mL (<1 mM)
Ethanol 6 mg/mL (20.38 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 33.98 mL 169.89 mL 339.79 mL
0.5 mM 6.8 mL 33.98 mL 67.96 mL
1 mM 3.4 mL 16.99 mL 33.98 mL
5 mM 0.68 mL 3.4 mL 6.8 mL

*The above data is based on the productmolecular weight 294.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10047
Actions Inhibitor
M. Wt 294.3
Formula C17H14N2O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 133550-30-8
Synonyms Tyrphostin AG490
SMILES C1=CC=C(C=C1)CNC(=O)/C(=C/C2=CC(=C(C=C2)O)O)/C#N

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