AG-490

Catalog No.: A10047
EGFR inhibitor
AG 490 is a selective inhibitor of EGF receptor tyrosine kinase (IC50 values are 2 and 13.5 μM for EGFR and ErbB2 respectively). Also inhibits JAK2 with no activity to Lck, Lyn, Btk, Syk and Src.
Grouped product items
Product Name Price Stock Qty
AG-490 10mg
Special Price $24.00 Regular Price $30.00
In stock
AG-490 50mg
Special Price $64.00 Regular Price $80.00
In stock
AG-490 100mg
Special Price $88.00 Regular Price $110.00
In stock
AG-490 200mg
Special Price $160.00 Regular Price $200.00
In stock
AG-490 10mM * 1mL in DMSO
Special Price $54.40 Regular Price $68.00
In stock
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Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Adooq's AG-490 has been cited by 1 publications
  • Matozaki M, .et al. , Exp Cell Res, 2019, Feb 15. pii: S0014-4827(18)31030-9 PMID: 30776355
  • Biological Activity
    Discription AG 490 is a selective inhibitor of EGF receptor tyrosine kinase (IC50 values are 2 and 13.5 μM for EGFR and ErbB2 respectively). Also inhibits JAK2 with no activity to Lck, Lyn, Btk, Syk and Src.
    Targets
    Target Value
    Product Information
    Catalog Num A10047
    Formula C17H14N2O3
    Molecular Weight 294.3
    CAS Number 133550-30-8
    SMILES C1=CC=C(C=C1)CNC(=O)/C(=C/C2=CC(=C(C=C2)O)O)/C#N
    Synonyms Tyrphostin AG490
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 54 mg/mL (183.48 mM)
    Water Insoluble
    Ethanol 6 mg/mL
    In vivo 5% DMSO+40% PEG300+5% Tween80+50% ddH2O 5.93 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 33.98 mL 169.89 mL 339.79 mL
    0.5 mM 6.8 mL 33.98 mL 67.96 mL
    1 mM 3.4 mL 16.99 mL 33.98 mL
    5 mM 0.68 mL 3.4 mL 6.8 mL
    Useful Calculator

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    This equation is commonly abbreviated as: C1V1 = C2V2

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