AG-490

Name: AG-490
Brand: Adooq Bioscience
SKU: A10047
Rating: 100 (1 reviews)

Catalog No.: A10047

EGFR inhibitor

Product Citations (1)

AG-490 Chemical Structure

CAS NO. 133550-30-8

AG 490 is a selective inhibitor of EGF receptor tyrosine kinase (IC50 values are 2 and 13.5 μM for EGFR and ErbB2 respectively). Also inhibits JAK2 with no activity to Lck, Lyn, Btk, Syk and Src.

Availability: In stock

Package	Price	Qty
10 mg	$30.00
50 mg	$80.00
100 mg	$110.00
200 mg	$200.00
10mM * 1mL in DMSO	$68.00
Custom Size	Get quote

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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable paper

Publications Citing Use of Adooq AG-490

Matozaki M, .et al. Involvement of Stat3 phosphorylation in mild heat shock-induced thermotolerance, Exp Cell Res, 2019, Feb 15. pii: S0014-4827(18)31030-9 PMID: 30776355

Biological Activity

AG 490 is a selective inhibitor of EGF receptor tyrosine kinase (IC50 values are 2 and 13.5 μM for EGFR and ErbB2 respectively). Also inhibits JAK2 with no activity to Lck, Lyn, Btk, Syk and Src.

Targets

EGFR (Cell-free assay)	JAK2 (Cell-free assay)	ErbB2 (Cell-free assay)
0.1 μM	~10 μM	13.5 μM

Solubility *

In vitro (25°C)	DMSO	54 mg/mL (183.48 mM)
	Water	Insoluble
	Ethanol	6 mg/mL
In vivo	5% DMSO+40% PEG300+5% Tween80+50% ddH2O	5.93 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	33.98 mL	169.89 mL	339.79 mL
0.5 mM	6.8 mL	33.98 mL	67.96 mL
1 mM	3.4 mL	16.99 mL	33.98 mL
5 mM	0.68 mL	3.4 mL	6.8 mL

*The above data is based on the productmolecular weight 294.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A10047
Actions	Inhibitor
CAS No.	133550-30-8
Formula	C17H14N2O3
M. Wt	294.3
Purity	>98%
Synonyms	Tyrphostin AG490
SMILES	C1=CC=C(C=C1)CNC(=O)/C(=C/C2=CC(=C(C=C2)O)O)/C#N
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.