BTK

Cat. No.

A11020

CAS No.

936563-96-1

Ibrutinib (PCI-32765)

Synonyms: PCI-32765

PCI-32765 is an orally bioavailable small-molecule inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity.

Cat. No.

A11348

CAS No.

910232-84-7

CGI1746

CGI1746 is a small-molecule Btk inhibitor chemotype with a new binding mode that stabilizes an inactive nonphosphorylated enzyme conformation.

Cat. No.

A12238

CAS No.

1599432-18-4

Ibrutinib-biotin

Ibrutinib-biotin is a probe that consists of Ibrutinib linked to biotin via a long chain linker, extracted from patent WO2014059368A1 Compound 1-5, has an IC50 of 0.755-1.02 nM for BTK.

Cat. No.

A12270

CAS No.

1022899-36-0

PCI-33380

PCI-33380 is an irreversible Bruton's Tyrosine Kinase (BTK) inhibitor (fluorescent probe).

Cat. No.

A12535

CAS No.

1242156-23-5

RN486

Synonyms: RN-486,RN 486

RN486 is a Bruton's tyrosine kinase (Btk) inhibitor.

Cat. No.

A12538

CAS No.

2095280-64-9

CHMFL-BTK-01

CHMFL-BTK-01 (compound 9) is a highly selective irreversible BTK inhibitor, with an IC50 of 7 nM. CHMFL-BTK-01 (compound 9) potently inhibited BTK Y223 auto-phosphorylation.

Cat. No.

A12706

CAS No.

1133432-46-8

GDC-0834 Racemate

Synonyms: GDC0834

GDC-0834 Racemate is a potent and selective inhibitor of Bruton's tyrosine kinase (BTK), investigated as a potential treatment for rheumatoid arthritis.

Cat. No.

A13202

CAS No.

1202757-89-8

AVL-292

Synonyms: CC292

AVL-292 is a highly selective, covalent Btk inhibitor.

Cat. No.

A13233

CAS No.

1202759-32-7

CNX-774

CNX-774 is a potent Btk inhibitor (IC50 < 1 nM)

Cat. No.

A15008

CAS No.

1360053-81-1

Spebrutinib besylate (AVL-292 benzenesulfonate)

Synonyms: AVL292 benzenesulfonate

AVL-292 benzenesulfonate is a covalent, highly selective, orally active small molecule inhibitor of Btk with IC50 value of 0.5 nM, >1400-fold selectivity over the other kinases assayed.

Cat. No.

A15558

CAS No.

1351635-67-0

ONO-4059 analog

Synonyms: GS 4059

ONO-4059 is a highly potent and selective oral BTK inhibitor

Cat. No.

A15824

CAS No.

1420477-60-6

Acalabrutinib (ACP-196)

Synonyms: ACP196

ACP-196 is an orally available inhibitor of Bruton–s tyrosine kinase (BTK) with potential antineoplastic activity. It inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway.

Cat. No.

A15976

CAS No.

1353550-13-6

Olmutinib (HM61713)

Synonyms: HM 61713; BI-1482694

Olmutinib is a potent small molecule inhibitor of Bruton's tyrosine kinase (BTK).

Cat. No.

A16260

CAS No.

1412418-47-3

(Rac)-IBT6A

(Rac)-IBT6A is a pyrazolo[3,4-d]pyrimidine derivative as a Btk kinase inhibitor.  

Cat. No.

A16261

CAS No.

244240-24-2

(Z)-LFM-A13

Synonyms: LFM A13

LFM-A13 is a potent and selective inhibitor of Btk with IC50 of 17.2 uM; also inhibits PLK3 with IC50 of 7.2 uM.

Cat. No.

A16262

CAS No.

330786-25-9

PCI 29732

PCI 29732 is a selective and irreversible Btk inhibitor with IC50 of 8.2 nM in a FRET based biochemical enzymology assay.

Cat. No.

A16263

CAS No.

1469988-75-7

QL47

Synonyms: BTK Inhibitor

QL47 is a potent, selective and irreversible BTK kinase inhibitor with IC50 of 7 nM.

Cat. No.

A16339

CAS No.

1434048-34-6

GDC0853

GDC0853 is a potent and orally BTK inhibitor.

Cat. No.

A16824

CAS No.

1415823-73-2

Evobrutinib

Synonyms: M-2951; MSC-2364447C

Evobrutinib is a highly selective BTK inhibitor with an IC50 of 37.9 nM. It has potential anti-neoplastic activity.

Cat. No.

A16905

CAS No.

1231889-53-4

BMS-935177

BMS-935177 a potent BTK inhibitor with improved kinase selectivity and superior oral exposure in multiple species. should provide useful clinical efficacy in autoimmune diseases.

Cat. No.

A17057

CAS No.

1558036-85-3

Btk inhibitor 2

Btk inhibitor 2 is a Bruton's tyrosine kinase (BTK) inhibitor.

Cat. No.

A17189

CAS No.

1510829-06-7

Vecabrutinib

Synonyms: SNS-062; FP-182; BSK-4841; BIIB-062

Vecabrutinib is a potent, noncovalent, reversible BTK inhibitor that inhibits signaling through the BCR pathway.

Cat. No.

A18022

CAS No.

936563-87-0

Ibrutinib Racemate

Synonyms: PCI-32765 (Racemate); PCI 32765

Ibrutinib Racemate (PCI-32765 Racemate) is the racemate of Ibrutinib. Ibrutinib is a selective, irreversible Btk inhibitor with IC50 value of 0.5 nM.

Cat. No.

A18589

CAS No.

2231744-29-7

MT-802

MT-802 is a potent BTK degrader based on PROTAC technology, with a DC50 of 1 nM. MT-802 has potential to treat C481S mutant chronic lymphocytic leukemia (CLL).

Cat. No.

A18612

CAS No.

1609465-89-5

PF-06250112

PF-06250112 is a potent, highly selective, orally bioavailable BTK inhibitor with an IC50 of 0.5 nM, shows inhibitory effect toward BMX nonreceptor tyrosine kinase and TEC with IC50s of 0.9 nM and 1.2 nM, respectively.