Fig. 1 · Structure
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AGI-16903
Metabolite
AGI-16903 is a metabolite of Enasidenib, functioning as a reversible and selective inhibitor of mutant isocitrate dehydrogenase 2 (IDH2) enzymes. It exhibits IC50 values of 100 nM and 400 nM for IDH2R140Q and IDH2R172K variants, respectively. This compound is primarily used in cancer research, particularly in studies focused on IDH2 mutations and their role in tumorigenesis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1643852-84-9 |
| Applications | Metabolite |
| Formula | C15H9F6N7 |
| Molecular Weight | 401.28 |
| SMILES | FC(F)(F)C1=NC(=CC=C1)C=2N=C(N=C(N2)NC=3C=CN=C(C3)C(F)(F)F)N |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.