Fig. 1 · Structure
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Agomelatine hydrochloride
MT1/2 Agonist
Agomelatine hydrochloride is a specific agonist of the melatonin receptors MT1 and MT2, demonstrating potent binding affinity with Kis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively. Additionally, it acts as a selective antagonist of the 5-HT2C receptor, exhibiting pKis of 6.4 and 6.2 for native (porcine) and cloned human receptors. Agomelatine hydrochloride is primarily utilized in research focusing on sleep disorders, depression, and circadian rhythm regulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 1176316-99-6 |
| Applications | MT1/2 Agonist |
| Formula | C15H18ClNO2 |
| Molecular Weight | 279.76 |
| Synonyms | S-20098 hydrochloride |
| SMILES | CC(NCCC1=C2C=C(OC)C=CC2=CC=C1)=O.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.