Fig. 1 · Structure
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Agomelatine (L(+)-Tartaric acid)
MT1/2 Agonist
Agomelatine (L(+)-Tartaric acid) is a potent agonist of the melatonin receptors MT1 and MT2, exhibiting binding affinities (Kis) of 0.1 nM, 0.06 nM, 0.12 nM, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively. Additionally, it functions as a selective antagonist of the 5-HT2C receptor, with pKis of 6.4 and 6.2 for native porcine and cloned human receptors, respectively. This compound is pivotal for research into mood disorders and the role of melatonin signaling in neurobiology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 824393-18-2 |
| Applications | MT1/2 Agonist |
| Formula | C19H23NO8 |
| Molecular Weight | 393.39 |
| Synonyms | S-20098 L(+)-Tartaric acid |
| SMILES | CC(NCCC1=C2C=C(OC)C=CC2=CC=C1)=O.O=C(O)[C@H](O)[C@@H](O)C(O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.