AGU654 is a selective mPGES-1 inhibitor with an IC50 of 2.9 nM, acting primarily on the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme. By inhibiting this enzyme, AGU654 disrupts the conversion of arachidonic acid to prostaglandin E2 (PGE2), thereby reducing inflammatory responses, pain, and fever. In cellular models, AGU654 effectively suppresses PGE2 production in response to bacterial exotoxins while maintaining the synthesis of other prostaglandins. Furthermore, in guinea pig models, it demonstrates significant anti-inflammatory, analgesic, and antipyretic properties, highlighting its potential for research in inflammatory diseases and pain management.
AGU654 is a selective mPGES-1 inhibitor with an IC50 of 2.9 nM, acting primarily on the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme. By inhibiting this enzyme, AGU654 disrupts the conversion of arachidonic acid to prostaglandin E2 (PGE2), thereby reducing inflammatory responses, pain, and fever. In cellular models, AGU654 effectively suppresses PGE2 production in response to bacterial exotoxins while maintaining the synthesis of other prostaglandins. Furthermore, in guinea pig models, it demonstrates significant anti-inflammatory, analgesic, and antipyretic properties, highlighting its potential for research in inflammatory diseases and pain management.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
