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AH22921

Prostaglandin Receptor Antagonist

AH22921 is a selective antagonist of the EP4 prostaglandin receptor, inhibiting the activation of adenylate cyclase by prostaglandins in CHO cells. This compound is characterized by its ability to shift the PGE2 concentration-response curve to the right, demonstrating its non-competitive antagonistic effect specifically on EP4 receptors. Notably, AH22921 does not influence the PGE2 concentration-response curve in NPE cells that express EP2 receptors, making it a valuable tool for studying EP4 receptor signaling in varied biological contexts.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	74480-23-2
Applications	Prostaglandin Receptor Antagonist
Formula	C₂₉H₃₅NO₅
Molecular Weight	477.59
SMILES	OC(CCC/C=C/C[C@H]1[C@H](N2CCOCC2)C(C[C@H]1OCC3=CC=C(C4=CC=CC=C4)C=C3)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.