Akt3 degrader 1

Catalog No.: A25861
Akt3 Degrader
Akt3 degrader 1 is a selective degrader that targets Akt3, effectively overcoming Osimertinib-induced resistance in H1975OR non-small cell lung cancer (NSCLC) cells. This compound demonstrates anti-proliferative effects and significantly inhibits tumor growth in murine models. Akt3 degrader 1 is a valuable tool for investigating mechanisms of drug resistance in NSCLC and can facilitate the development of novel therapeutic strategies.
Grouped product items
Size Price Stock Qty
1mg
$155.00
In stock
5mg
$395.00
In stock
10mg
$580.00
In stock
25mg
$905.00
In stock
50mg
$1,220.00
In stock
100mg
$1,570.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionAkt3 degrader 1 is a selective degrader that targets Akt3, effectively overcoming Osimertinib-induced resistance in H1975OR non-small cell lung cancer (NSCLC) cells. This compound demonstrates anti-proliferative effects and significantly inhibits tumor growth in murine models. Akt3 degrader 1 is a valuable tool for investigating mechanisms of drug resistance in NSCLC and can facilitate the development of novel therapeutic strategies.
Product Information
Catalog NumA25861
FormulaC53H72N8O4
Molecular Weight885.19
CAS Number2836342-69-7
SMILESCOC1=C(C=CC(N2CCN(CC2)CCCCCCCCCCCCNC(CC34CC5CC(C4)CC(C3)C5)=O)=C1)NC6=NC=C7C(C)=CC(N(C7=N6)C8=CC=CC(NC(C9CC9)=O)=C8)=O
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