Fig. 1 · Structure
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Aladorian sodium
RyR2 Stabilizer
Aladorian sodium is a non-peptidic stabilizer of the ryanodine receptor 2 (RyR2). It effectively stabilizes RyR2 channels and rectifies abnormal Ca²⁺ handling in cardiomyocytes, thereby improving calcium homeostasis independent of dystrophin restoration. This compound has been shown to attenuate early cardiomyopathy and enhance left ventricular function in canine models of muscular dystrophy. Aladorian sodium is applicable in research related to heart failure, Duchenne muscular dystrophy-associated cardiomyopathy, and general muscular dystrophy.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Stabilizer |
| CAS Number | 1233219-11-8 |
| Applications | RyR2 Stabilizer |
| Formula | C12H12NNaO4S |
| Molecular Weight | 289.28 |
| Synonyms | ARM036 sodium; S44121 sodium |
| SMILES | O=C(C(N1CCSC2=CC=C(C=C2C1)OC)=O)O[Na] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.