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ALK Inhibitor

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Catalog No. A11134

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
CH5424802 5mg A11134-5

Regular Price: €76.00

Special Price: €68.40

CH5424802 10mg A11134-10

Regular Price: €114.00

Special Price: €102.60

CH5424802 50mg A11134-50

Regular Price: €237.50

Special Price: €213.75

CH5424802 100mg A11134-100

Regular Price: €427.50

Special Price: €384.75

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

CH5424802 is a potent, selective, and orally available ALK inhibitor with a unique chemical scaffold, showing preferential antitumor activity against cancers with gene alterations of ALK.


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Chemical Information

Catalog Num A11134
Actions Inhibitor
M. Wt 482.6
Formula C30H34N4O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1256580-46-7
Synonyms CH-5424802

Biological Activity

CH5424802 is a potent, selective, and orally available ALK inhibitor with a unique chemical scaffold, showing preferential antitumor activity against cancers with gene alterations of ALK.
Target Value
ALK(F1174L)IC50: 1nM
ALKIC50: 1.9nM
ALK(R1275Q)IC50: 3.5nM
INSRIC50: 550nM
KDRIC50: 1.4μM
AblIC50: >5μM
EGFRIC50: >5μM
FGFR2IC50: >5μM
HER2IC50: >5μM
IGF-1RIC50: >5μM
JAK1IC50: >5μM
KitIC50: >5μM
MetIC50: >5μM
PDGFRβIC50: >5μM
SrcIC50: >5μM
Akt1IC50: >5μM
Akt2IC50: >5μM
Akt3IC50: >5μM
AuroraAIC50: >5μM
CDK1IC50: >5μM
CDK2IC50: >5μM
MEK1IC50: >5μM
PKAIC50: >5μM
PKCαIC50: >5μM
PKCβ1IC50: >5μM
PKCβ2IC50: >5μM
Raf-1IC50: >5μM


Solubility (25°C) * In vitro DMSO 2 mg/mL heating (4.14 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.72 mL 103.61 mL 207.21mL
0.5 mM 4.14 mL 20.72 mL 41.44 mL
1 mM 2.07 mL 10.36 mL 20.72 mL
5 mM 0.41 mL 2.07 mL 4.14 mL

*The above data is based on the productmolecular weight 482.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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