CH5424802

Catalog No.: A11134

ALK Inhibitor

CH5424802 Chemical Structure

CAS NO. 1256580-46-7

CH5424802 is a potent, selective, and orally available ALK inhibitor with a unique chemical scaffold, showing preferential antitumor activity against cancers with gene alterations of ALK.

Availability: In stock

Package Price Qty
5 mg
$65.00
10 mg
$80.00
50 mg
$110.00
100 mg
$175.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

CH5424802 is a potent, selective, and orally available ALK inhibitor with a unique chemical scaffold, showing preferential antitumor activity against cancers with gene alterations of ALK.
Targets
Target Value
ALK(F1174L)IC50: 1nM
ALKIC50: 1.9nM
ALK(R1275Q)IC50: 3.5nM
INSRIC50: 550nM
KDRIC50: 1.4μM
AblIC50: >5μM
EGFRIC50: >5μM
FGFR2IC50: >5μM
HER2IC50: >5μM
IGF-1RIC50: >5μM
JAK1IC50: >5μM
KitIC50: >5μM
MetIC50: >5μM
PDGFRβIC50: >5μM
SrcIC50: >5μM
Akt1IC50: >5μM
Akt2IC50: >5μM
Akt3IC50: >5μM
AuroraAIC50: >5μM
CDK1IC50: >5μM
CDK2IC50: >5μM
MEK1IC50: >5μM
PKAIC50: >5μM
PKCαIC50: >5μM
PKCβ1IC50: >5μM
PKCβ2IC50: >5μM
Raf-1IC50: >5μM
In vitro (25°C) DMSO 2 mg/mL heating (4.14 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.72 mL 103.61 mL 207.21 mL
0.5 mM 4.14 mL 20.72 mL 41.44 mL
1 mM 2.07 mL 10.36 mL 20.72 mL
5 mM 0.41 mL 2.07 mL 4.14 mL

*The above data is based on the productmolecular weight 482.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11134
Actions Inhibitor
M. Wt 482.6
Formula C30H34N4O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1256580-46-7
Synonyms CH-5424802
SMILES CCC1=C(C=C2C(=C1)C(=O)C3=C(C2(C)C)NC4=C3C=CC(=C4)C#N)N5CCC(CC5)N6CCOCC6

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