Fig. 1 · Structure
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ALK5-IN-28
ALK-5 Inhibitor
ALK5-IN-28 is a selective inhibitor of ALK-5 with an IC50 of ≤ 10 nM, effectively blocking TGF-β-induced SMAD signaling pathways. This compound demonstrates significant potential in inhibiting tumor growth in vivo, making it valuable for research into proliferative diseases such as cancer. Its precise action on the ALK-5 target allows for targeted investigations into therapeutic strategies against TGF-β-mediated tumorigenesis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2785430-84-2 |
| Applications | ALK-5 Inhibitor |
| Formula | C25H27N7 |
| Molecular Weight | 425.53 |
| SMILES | CC1=CC=CC2=C(NC3=NC(NC4=CC=C(CC5CCNCC5)C=C4)=NC=C3)C=NN=C12 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.